diff --git a/src/core/hle/kernel/thread.cpp b/src/core/hle/kernel/thread.cpp
index e308b9c7b..5f87ff859 100644
--- a/src/core/hle/kernel/thread.cpp
+++ b/src/core/hle/kernel/thread.cpp
@@ -23,6 +23,7 @@
 #include "core/hle/kernel/object.h"
 #include "core/hle/kernel/process.h"
 #include "core/hle/kernel/thread.h"
+#include "core/hle/lock.h"
 #include "core/hle/result.h"
 #include "core/memory.h"
 
@@ -104,6 +105,10 @@ void ExitCurrentThread() {
  */
 static void ThreadWakeupCallback(u64 thread_handle, int cycles_late) {
     const auto proper_handle = static_cast<Handle>(thread_handle);
+
+    // Lock the global kernel mutex when we enter the kernel HLE.
+    std::lock_guard<std::recursive_mutex> lock(HLE::g_hle_lock);
+
     SharedPtr<Thread> thread = wakeup_callback_handle_table.Get<Thread>(proper_handle);
     if (thread == nullptr) {
         LOG_CRITICAL(Kernel, "Callback fired for invalid thread {:08X}", proper_handle);